FASTest C. perfringens Toxin

Qualitative Detection Of Clostridium Perfringens Enterotoxin

Test applicable to: Companion and Farm Animals

Sample: Faeces

The gram-positive anaerobic bacterium Clostridium perfringens belongs to the physiological intestinal flora of many mammals and is a facultative pathogenic. Inconvenient endogenous (other basic diseases, diarrhoea pathogens, antibiotic therapies with massive reduction of intestinal flora etc.) and exogeneous (farming conditions, extreme changes of the food, stress etc.) factors can lead to an increased pathogenicity of C. perfringens. In addition to its ability to form extremely infectious and stable spores, the formation of lethal toxins is crucial for its pathogenicity. The classification into the various types (A–E) is only due to the toxin formation.

Clostridium Perfringens Toxins Cause Mild to Lethal Conditions

These toxins can cause extremely variable (mild to lethal progression forms) failures of the intestinal water and electrolyte balance in the different species such as goat, sheep (e. g. dysentery of lambs: type B; pulpy kidney disease: type D), cattle (haemorrhagic enteritis: type A–E), foal (haemorrhagic necrotising enteritis: type A & C) and piglet (e. g. serous-catarrhal enteritis: type A, necrotising enteritis: type C).

CPE Detected More Often In Dogs

In the dog, especially serotype A occurs, producing 2 main toxins (toxin Alpha [α] and a Clostridia enterotoxin [CPE]), rarer serotype B (toxin Beta [β]). Both C. perfringens and its CPE can be detected also in healthy dog’s faeces. The CPE can be detected more often in dogs with diarrhoea compared to healthy dogs. CPE is more frequent in dogs with diarrhoea (haemorrhagic gastroenteritis, acute or chronic diarrhoea, enterotoxaemia) than in healthy dogs. Meanwhile for cats, reliable literature data concerning prevalence and clinical relevance are missing.

FASTest C. perfringens Toxins Allows Rapid Onsite Diagnosis

Detection is only by the presence of C. perfringens in the faeces, Clostridia is undiagnosable. In a study in Switzerland, 54 % of the C. perfringens isolated showed a reduced sensitivity towards metronidazole or 18 % towards tetracycline. Because there is a general risk of resistance formation, it is recommended to identify the triggering pathogen in principle. Finally, by its high sensitivity and specificity, the use of FASTest® C. perfringens Toxin allows the veterinarian a rapid aetiological on-site diagnosis of a C. perfringens infection, the quick initiation of therapy as well as of necessary quarantine and prophylaxis measures.

FASTest C. perfringens Product Information

In summary, diarrhoea can have other causes. Therefore, it is generally advisable to use the species-specific parallel tests.

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FASTest D-PHYTE Strip

Qualitative Detection Of Veterinary Relevant Dermatophytes

Test applicable to: Companion and Farm Animals

Sample: Skin scrapings, dandruff, plucked hairs, claws, feathers

Dermatophytosis/ringworm

Dermatophytosis/ringworm belong to the most frequent infectious dermatoses in small pets, companion animals and farm animals, but also in humans (zoonosis).

Cause of Dermatophytosis

They are caused by dermatophytes, filamentous fungi using keratin (skin, hair, claws and horns) as carbon source. The clinically most relevant vet. species are Trichophyton (T. verrucosum), Nannizzia (N. gypsea [earlier Microsporum gypseum], N. persicolor [earlier Microsporumpersicolor / Epidermophyton persicolor / Trichophyton mentagrophytes]) and Microsporum (M. canis).

Factors

Beside age and immunosuppression, breeding (especially persian cats) and living conditions (breeding, animal shelter, hunting dog, multiple species keeping), travelling, lactation (transmission of infection to puppies) as well as e.g. ectoparasite based diseases and debilitated animals play an important role in developing a ringworm disease. Warm and humid climate is an additional trigger.

Clinical Diagnosis

The FASTest® D-PHYTE Strip guarantees a rapid clarification of the suspected clinical diagnosis and thus enables the veterinarian to quickly and reliably identify dermatophytosis and initiate a specific therapy.

FASTest-D-PHYTE-Product-Information

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FASTest CRYPTO Strip – Cryptosporidium

For The Detection Of Cryptosporidium Parvum Antigens

Test applicable to: Small Animals, Companion Animals and Farm Animals
Sample: Faeces

Crypto Strip Test Principle

The FASTest CRYPTO Strip contains two unique monoclonal antibodies. Positive faeces samples contain Cryptosporidiosis parvum surface antigens (SA) as well as all of its vegetative cycle forms. These antigens will react in the conjugate pad area with mobile monoclonal Anti-Cryptosporidiosis parvum-Antibodies (Anti Cryptosporidiosis parvum.-mAb) which are bound to red latex particles. Migrating along the nitrocellulose membrane these specific antigen-antibody-complexes are bound from fixed Anti-Cryptosporidiosis parvum-mAb at the Test zone producing a more or less red Test line. This Anti-Cryptosporidiosis parvum-mAb guarantees a high level of specificity for the aetiologic detection of Cryptosporidiosis parvum.

The Correct Test Procedure

The correct test procedure is provided by the occurrence of an intense blue Control line at the Control zone. The intensity/width of the test line depends on the concentration of Cryptosporidiosis parvum surface antigens in the test sample volume. Therefore, FASTest CRYPTO Strip does not depend on the presence of intact Cryptosporidium parvum oocysts or its other vegetative forms.

FASTest CRYPTO strip is a valuable on-site tool for the diagnosis and treatment of Cryptosporidiosis in a wide range of animals.

FASTest Crypto Product Information – PDF Download

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FASTest EHRLICHIA canis

Detection Of Antibodies Against Ehrlichia canis

Test applicable to: Dog
Sample: Whole blood, Serum or Plasma

The FASTest EHRLICHIA canis test kit is a rapid immunochromatographic screening test for the detection of anti-Ehrlichia canis antibodies. It can be used with serum, plasma or whole blood up to 28 days after infection. The method employs a unique combination of a specific labelled antigen, which is conjugated on dye particles, and this protein is immobilized to the solid phase membrane.

Fast, Routine Check After Travelling Abroad

As the test sample flows laterally across the membrane, the specific labelled antigen protein binds to the anti-Ehrlichia canis antibodies in the sample. Then, if the sample contains anti- Ehrlichia canis antibodies, the complex binds to the antigen on the solid phase in the TEST window (B) producing a pink-purple line. In the absence of anti-Ehrlichia canis antibodies, there is no line in the TEST window (B). The liquid continues to migrate along the membrane and produces a pink-purple line in the CONTROL window (C) demonstrating that the reagents are functioning properly.

FASTest EHRLICHIA Product Information – PDF Download

FASTest LYME

Qualitative Detection Of Antibodies Against Borrelia burgdorferi

Test applicable to: Dog
Sample: Whole Blood, Plasma or Serum

FASTest LYME is a rapid immunochromatographic test for the detection of Borrelia burgdorferi IgG antibodies in the anti-coagulated whole blood, serum or plasma of infected dogs.

Test Principle

FASTest LYME is based on a rapid immunochromatographic technique. At the conjugate pad Borrelia burgdorferi sensu lato antibodies in the sample react with mobile gold labelled antibodies. Migrating along the nitrocellulose membrane “lateral flow”, these immune complexes bind to fixed recombinant Borrelia antigens, building up a pink-purple test line (B) in the reaction window. A correct test procedure will be indicated by a second pink-purple control line (C) in the reaction window.

FASTest LYME Product Information – PDF Download

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FASTest Brucella Canis

Qualitative Detection Of IgG Antibodies Against Brucella Canis 

Test applicable to: Dog
Sample: Whole blood, Plasma or Serum

FASTest Brucella Canis is a rapid immunochromatographic test for the detection of IgG antibodies in the anti-coagulated whole blood, plasma or serum of dogs. Showing high Sensitivity of 90.5% and Specificity of 88.4%, FASTest Brucella Canis test kit enables the veterinarian to confirm quickly and on-site an estimated diagnosis and to start therapy and a Brucellosis Prevention Program adapted to the breeder’s needs.

Abortions and Reproductive Failures

Brucellosis in the dog shows low prevalence but occurs most commonly after ingestion of contaminated placental materials or aborted foetuses, vaginal discharges from infected bitches that are in heat or who abort, and during breeding. Following an abortion, Brucella Canis may be shed for several weeks or, intermittently, for months.

Brucella Canis is a zoonotic organism and it is different for male and female dogs. Treatment for the disease can often be very expensive and it is thought that a combination of minocycline and streptomycin is useful but unaffordable.

FASTest Brucella canis Product Information – PDF Download

FASTest LEISH

Qualitative Detection Of Antibodies Against Leishmania infantum

Test applicable to: Dog
Sample: Whole Blood, Serum or Plasma

FASTest LEISH is a rapid immunochromatographic test for the detection of Leishmania infantum IgG-Antibodies in the anti-coagulated whole blood, serum or plasma of dogs using a simple lateral flow principle for the detection of the antibodies which are present.

Routine Check After Travelling Abroad 

If there are any antibodies present in the sample they will reach the conjugate pad and react with mobile monoclonal antibodies labelled with gold particles.

FASTest LEISH Product Information – PDF Download

FASTest LH

Qualitative Detection Of Luteinising Hormone

Test applicable to: Dog and Cat
Sample: Serum or Plasma
 
Temporarily Discontinued 

FASTest LH is a rapid immunochromatographic lateral flow test for the detection of Luteinising Hormone (LH) in the serum/plasma of dogs and cats.

Planning Whelping Date in Dogs

By determining the LH peak, the date of birth can be predicted precisely on +/- one day by addition of 65 days of average duration of a dog’s pregnancy. This will then enable the veterinarian or breeder to prepare all of the necessary precautions for an easy and uncomplicated birth.

Fertility Status 

FASTest LH is a reliable on-site screening test for both cats and dogs for differentiation between fertile/uncastrated (intact ovaries) and infertile/castrated (ovariectomy or hormonally castrated animals) as well as in the bitch for optimal determination of ovulation time, mating time, artificial inseminating time and also for determination of expected date of whelping.

FASTest LH Product Information – PDF Download

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FASTest FCoV Strip – Feline Coronavirus

Qualitative Detection Of Feline Coronavirus Antigen

Test applicable to: Cat
Sample: Faeces

FASTest FCoV Strip is a rapid immunochromatographic lateral flow test for the detection of Feline Coronavirus antigen and is only for use in cats.

Feline Infectious Peritonitis And Feline Coronavirus

Feline Coronavirus is a worldwide virus and can affect domesticated and wild cats occasionally causing a chronic and progressive, often fatal disease, called Feline Infectious Peritonitis. Feline Infectious Peritonitis occurs sporadically in cats infected with  Feline Coronavirus (FCoV) which has mutated into a FCoV variant (FIPV). Based on the latest scientific knowledge, a Feline Infectious Peritonitis infection is not transmitted from one cat to another.

FASTest FCoV Product Information

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FASTest Distemper Strip

For The Detection Of Canine Distemper Virus

Test applicable to: Dog
Sample: Nasal/Ocular Discharge

FASTest DISTEMPER strip is a rapid immunochromatographic test for the detection of Canine Distemper Virus antigen in nasal and ocular discharge from infected dogs and other susceptible species. It is a highly contagious viral illness with no known cure to date. As well as domestic dogs, Distemper can affect certain species of wildlife including raccoons, wolves, foxes and skunks.

What Causes Canine Distemper Virus?

Canine distemper is caused by a paramyxovirus that is highly contagious. Distemper should be considered in the diagnosis of any febrile condition in puppies with multisystemic manifestations. While the typical clinical case is not difficult to diagnose, the characteristic signs sometimes fail to appear until late in the disease. The degree of viraemia and extent of spread of the virus to various tissues is moderate judged by the level of specific humoral immunity in the host during the viraemic period.

FASTest DISTEMPER Strip is a sensitive, reliable and specific immunochromatographic assay designed to detect canine distemper virus antigen in nasal and ocular discharge.

FASTest Distemper Product Information – PDF Download

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